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2008 Jun
For example, VIR-2218, a GalNAc-siRNA conjugate that targets HBV, uses enhanced stability chemistry plus technology to stabilize the siRNA in vivo and reduce off-target effects
Greenberg Z, Gavish H, Muhlrad A, Chorev M, Shteyer A, Attar-Namdar M, et al
Research theme: Biochemistry Biochemical properties of TRP14 (TXNDC17) The thioredoxin-fold protein named TRP14 (thioredoxin Related Protein of 14 kDa), which is encoded by TXNDC17 in human (for thioredoxin domain-containing 17), is an interesting and little-studied protein that is ubiquitously expressed in cells in parallel with thioredoxin, a good substrate for thioredoxin reductase, but is not capable of reducing typical thioredoxin substrates such as ribonucleotide reductase, peroxiredoxins or methionine sulfoxide reductases
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